Joi, 17 februarie
Rubin Kazan – FC Twente Enschede 0-2
Metalist Harkov – Bayer Leverkusen 0-4
SSC Napoli – CF Villarreal 0-0
RSC Anderlecht Bruxelles – Ajax Amsterdam 0-3
Lech Poznan – SC Braga 1-0
Besiktas Istanbul – Dinamo Kiev 1-4
Benfica Lisabona – VfB Stuttgart 2-1
BATE Borisov – Paris Saint Germain 2-2
Glasgow Rangers – Sporting Lisabona 1-1
Sparta Praga – FC Liverpool 0-0
FC Basel – Spartak Moscova 2-3
Young Boys Berna – Zenit St. Petersburg 2-1
PAOK – TSKA Moscova 0-1
FC Sevilla – FC Porto 1-2
OSC Lille – PSV Eindhoven 2-2
Returul se va desfasura pe 22-24 februarie 2011.